When you develop swollen gums in the area of your mouth from dentures, it is best to do what comes naturally. If you are uncomfortable, you probably have a soft tissue injury. Take the denture out an leave it for an hour or so. In most cases that takes care of it. If you have developed a red spot, it is advisable to go dentureless for 24 hours. Then if the condition does not clear up, or if the soreness returns when you start using your dentures again, see you dentist as soon as possible. Your dentist can detect and can give the best solution to your problems concerning the mouth.